4 edition of Blood flow-induced remodeling of arterial elastin found in the catalog.
Blood flow-induced remodeling of arterial elastin
Thesis (M.Sc.) -- University of Toronto, 1994.
|Series||Canadian theses = -- Thèses canadiennes|
|The Physical Object|
|Pagination||2 microfiches : negative. --|
Blood pressure can be used as an indicator of an individual’s risk for cardiovascular disease. The common practice of blood pressure measurement using a cuff-based system provides a snapshot of blood pressure at a single instance in time and can be inconvenient and intrusive. Purpose: The purpose of this study was to evaluate the effects of a distal arteriovenous fistula (dAVF) on the morphologic changes occurring in arterial bypass grafts by the use of a novel experimental model. Methods: Aortofemoral bypass grafts with or without dAVFs were constructed in 36 Sprague-Dawley rats with a microsurgical technique. The bypass graft material consisted of Cited by:
The blood flow to an active muscle changes depending on the exercise intensity, contraction frequency, contraction-to-relaxation duty cycle, etc [1–9].The blood flow increases markedly during the relaxation phase of dynamic exercise, whereas it remains at a lower level during the contraction period [10–14].Thus, the magnitude of the blood flow during the relaxation phase of the Cited by: 5. Methods. Eight polymorphisms located in MMP-2 and MMP-9 were genotyped, and the association of these variations with disease was assessed in a Caucasian population consisting of patients with intracranial aneurysms and ethnically matched healthy volunteers.. Polymorphisms in the MMP-2 gene and the haplotypes generated from these polymorphisms were not associated with Cited by:
This chapter summarizes the current knowledge regarding the regulation of the tone of cerebral resistance arteries under conditions of normal health and with the development of chronic diseases (e.g., metabolic disease). The work integrates the myogenic (pressure-induced) regulation of vascular tone, the impact of elevated luminal flow or shear stresses, that of local tissue metabolic activity. After joining the Rabinovitch Lab in September of , Dan applied an integrative omics approach to relate metabolic changes to chromatin remodeling and gene regulation responsible for the hyperproliferative phenotype of pulmonary arterial smooth muscle cells in .
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Flow-induced arterial remodeling has important links to atherosclerosis. During lesion development, arterial remodeling is an adaptive response that helps maintain lumen size (Glagov phenomenon). 5 On the other hand, activation of proinflammatory mechanisms during the remodeling process may contribute to plaque vulnerability, restenosis, and cardiovascular events.
6–8 Remodeling depends on Cited by: Introduction. Collagen and elastin are two vital components of the blood vessel. Conduit arteries like the carotid and femoral artery and the aorta may undergo remodeling in response to structural modifications in these proteins.1 Elastin comprises 90% of elastic arterial fibers.2 Elastin enables many tissues in the body to resume their shape after stretching or by: Lemkens et al.
() studied flow-induced remodeling in mesenteric small arteries (– µm in diameter) in DOCA-salt HT rats; they studied the effects of BF changes by the distal ligation of alternate first-order mesenteric arteries.
They obtained the results showing that arterial diameter increased and decreased responding to increase Cited by: 8. The half-life for collagen in human arteries is many months, and for elastin it is years to decades.
These data argue that vascular structures are extremely stable. Nonetheless, vascular tissues in individual arteries undergo substantial remodeling whenever the blood flows they Cited by: According to certain experimental findings, arterial remodeling in response to increased flow might be accompanied by structural changes in elastin.
Kagan et al. () found that lysyl oxidase, which catalyzes the incorporation of elastin into the matrix, is localized at the inner and outer surface of Cited by: Langille B.L. () Blood flow, Shear Stress and Remodeling of the Artery Wall.
In: Lafont A., Topol E.J. (eds) Arterial Remodeling: A Critical Factor in Restenosis. Developments in Cardiovascular Medicine, vol Cited by: 2. Both increased and decreased blood flow induced a significant increase in the number of macrophages (P Cited by: Arterial Remodeling in Response to Increased Blood Flow Using a Constituent-Based Model Article in Journal of Biomechanics 42(4) February with 17 Reads How we measure 'reads'.
A Model of Arterial Adaptation to Alterations in Blood Flow Article in Journal of Elasticity 61(1) April with 16 Reads How we measure 'reads'. However, WHS was returned to the control level of approximately kPa at 4 weeks after the release of constriction, indicating a blood pressure-mediated remodeling of arterial wall.
Fig. Ratio of wall thickness to internal diameter determined at in vivo working blood pressure before the release of constriction (BR), and soon after (0 wk Cited by: 2.
Mechanisms of Arterial Remodeling in Hypertension Coupled Roles of Wall Shear and Intramural Stress a blood flow–induced wall shear stress w, a blood persist into maturity because of the long half-life of elastin.6 Mean values of these 3 components of stress (ie, forces acting over oriented areas).
Arterial remodeling in response to sustained alterations in blood pressure and/or flow induces changes in vessel geometry, structure, and composition.
In conditions of hypertension and elevated blood flow, remodeling results in increased vessel mass that is distributed in a manner to maintain the local mechanical environment of the vascular Author: Tarek Shazly, Alexander Rachev. First, the deviation of the wall stress and flow-induced shear stress from their normal physiological values drives the changes in the arterial geometry.
Second, the new mass that is produced during remodeling results from an increase in the mass of smooth muscle cells and collagen by: Mechanisms of Arterial Remodeling in Hypertension: Coupled Roles of Wall Shear and Intramural Stress.
a blood flow induced wall shear stress Much can be learned about load-induced fragmentation of elastin in hypertension from the literature on arterial ag Similarly, Marfan syndrome, due to a mutation in the fibrillin-1 gene Cited by: Arterial remodeling and arterial function: basic concepts Arterial remodeling.
An arterial wall alters its structure and function in response to direct injury and atherogenic factors or to changes in haemodynamic burden (Fig. 2) .The structural modifications induced by haemodynamic alterations are changes in arterial lumen and/or arterial wall thickness due to activation, proliferation and Cited by: Proprotein convertases (PCSKs) process matrix metalloproteases and cytokines, but their function in the vasculature is largely unknown.
Previously, we demonstrated upregulation of PCSK6 in atherosclerotic plaques from symptomatic patients, localization to smooth muscle cells (SMCs) in the fibrous cap and positive correlations with inflammation, extracellular matrix remodeling and cytokines.
This idea is the underlying premise in studies of growth and remodeling in blood vessels. 37 Surgical arteriovenous fistulas created to enable hemodialysis provide clear evidence that this flow-induced vessel remodeling takes place in humans.
23,64 In these fistulas, the lack of capillary bed resistance produces an abnormally high flow, which Cited by: 7. The article "Wall Tissue Remodeling Regulates Longitudinal Tension in Arteries" in the journal Circulation Research describes how changes in blood pressure or blood flow induced arterial remodeling that normalizes mechanical loads that are imposed on arterial tissue.
In other words, increased blood flow/pressure in the artery forces the artery. During pregnancy, the uterine artery (UA) undergoes extensive remodeling to permit a 20–40 fold increase in blood flow with associated changes in the expression of a multitude of genes.
This study used next-gen RNA sequencing technology to identify pathways and genes potentially involved in arterial adaptations in pregnant rat UA (gestation day 20) compared with non-pregnant rat UA (diestrus).Author: Kathirvel Gopalakrishnan, Sathish Kumar.
Temporal events underlying arterial remodeling after chronic flow reduction in mice: Correlation of structural changes with a deficit in basal nitric oxide synthesis. Circ Res. ;–  Lu X, Zhao JB, Wang GR, Gregersen H, Kassab GS.
Remodeling of the zero-stress state of femoral arteries in response to flow by: 2. Essential or primary hypertension is defined as a medical condition denoted by consecutive high (above 90 mmHg) blood pressure readings in the absence of a known causal disease It is the result of elevated arterial pressure associated with increased cardiac output, total peripheral resistance, or both Unfortunately, mystery exists /5.
Elastin is a protein that coils and recoils like a spring within the. elastic fibers of connective tissue and accounts for the stretching. of structures such as the skin, blood vessels, heart, intestines and. penis.
Elastin functions in connective tissue function together with. collagen. Whereas collagen provides rigidity to connective tissue,5/5(11).Biomechanics relates the function of a physiological system to its structure.
The objective of biomechanics is to deduce the function of a system from its geometry, material properties and boundary Cited by: